KMID : 0545119950050040234
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Journal of Microbiology and Biotechnology 1995 Volume.5 No. 4 p.234 ~ p.237
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Production of Gericudranins by Hairy Root Culture of Cudrania tricuspidata
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Seo, Weon Taek
Lee, In Kyoung/Yoo, Ick Dong/Park, Young Hoon
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Abstract
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Production of new flavanol derivatives with cytotoxic activity, gericudranin A and B, was studied by using hairy root cultures of Cudrania tricuspidata. Schenk and Hildebrandt (SH) medium was chosen for root growth and gericudranin production. After 35 days culture in a half-strength liquid SH medium containing 30 g^glucose/§¤ hairy root growth reached 138 g^Fw/§¤ and gericudranin A and B were produced at concentrations of 27 §·/§¤ and 21 §·/§¤, respectively. It was also observed that the contents of gericudranin A and B in hairy root were eight and six times higher than those of cudraniae radix, respectively.
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